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Table 2 Effect of daily bolus injection of NS398 (10 mg/kg, i.p.) on the increases in tissue proinflammatory cytokine levels in the hippocampus following intraperitoneal infusion of Escherichia coli lipopolysaccharide (LPS, 2.5 mg/kg/day) for 7 days

From: Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus

Cytokines Treatment
(pg/100 μg protein) Saline LPS LPS + DMSO LPS + NS398
IL-1β 968 ± 79 1224 ± 106* 1145 ± 154* 868 ± 91**
IL-6 365 ± 45 577 ± 72* 613 ± 98* 416 ± 65**
TNF-α 191 ± 24 272 ± 38* 259 ± 36* 180 ± 28**
  1. Data are mean ± S.E.M., n = 6-8 animals per group
  2. * P < 0.05 versus saline group; ** P < 0.05 versus LPS group in the Scheffé multiple-range test
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