Table 2 Effect of daily bolus injection of NS398 (10 mg/kg, i.p.) on the increases in tissue proinflammatory cytokine levels in the hippocampus following intraperitoneal infusion of Escherichia coli lipopolysaccharide (LPS, 2.5 mg/kg/day) for 7 days

IL-1β

968 ± 79

1224 ± 106^*

1145 ± 154^*

868 ± 91^**

IL-6

365 ± 45

577 ± 72^*

613 ± 98^*

416 ± 65^**

TNF-α

191 ± 24

272 ± 38^*

259 ± 36^*

180 ± 28^**