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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Structural basis of blocking integrin activation and deactivation for anti-inflammation

Fig. 2

Integrin activator talin and co-activator kindlin. a The auto-inhibition of talin is release either by phosphorylation or partial proteolysis. b Recruitment of talin to integrin is mediated by binding Rap1-RIAM complex. c Binding of talin to the integrin triggers the dissociation of the α/β integrin cytoplasmic domains, thereby inducing active extended conformation. d Kindlin acts as a co-activator to stabilize integrin-mediated cell adhesion that involves multivalent ligand binding

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