Fig. 6

Drug induced-circling behavior in hemiparkinsonian rats at two weeks after transfecting the substantia nigra using NTS-polyplex. One week after a 6-OHDA striatal injection treatments were applied into the substantia nigra (arrow) as follows; without transfection, Dulbecco’s Modified Eagle Medium injection (DMEM), phDAT-EGFP or phDAT-BDNF-flag transfection. Ipsilateral circling behavior was included by amphetamine (8 mg/Kg, i.p.), whereas contralateral circling behavior was induced by apomorphine (0.5 mg/kg, s.c.) at weeks 1 (before treatment; n =28 animals) and 3 weeks after the striatal 6-OHDA lesion; n = 4 for the NT group and n = 8 animals for the rest of the groups. * P < 0.05, when compared with the values measured at week 1. † P < 0.05 when compared individually with the values of the other groups at week 3. Kruskal-Wallis test with Dunns post hoc test