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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson’s disease

Fig. 7

Spontaneous motor behavior of hemiparkinsonian rats in an open field at two weeks after transfecting the substantia nigra using NTS-polyplex. SHAM refers to the group of rats with a false lesion. One week after a 6-OHDA striatal injection treatments were applied into the substantia nigra as follows: without transfection (NT), injection with Dulbecco’s Modified Eagle Medium (DMEM), and transfection with phDAT-EGFP (GFP) or phDAT-BDNF-flag (BDNF). Values are expressed as the mean ± SE; n = 8 animals per group. ** P < 0.01, *** P < 0.001 vs. SHAM. One-way ANOVA with Bonferroni’s post hoc test

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Journal of Biomedical Science

ISSN: 1423-0127