Fig. 1
From: Molecular characterisation of plasma membrane-derived vesicles
Schematic presentation of modes of emission of PMVs vs. Exosomes. This figure shows the formation of an endosome by invagination. By inward blebbing of the endosomal membrane, intraluminal vesicles are formed. Endosomes containing intraluminal vesicles are called multivesicular bodies (MVBs). Cells release the contents of their MVB when the membrane of the MVB fuses with the plasma membrane and in contrast to exosomes, PMVs are formed by major structural rearrangements of the cytoskeleton and are ‘budded’ off from the outer cell membrane