Fig. 4From: Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivoColony formation after combination treatment. TW1 and TW4 cells were exposed to 50 or 60 μM each of NEO212, TMZ, or POH individually, as well as to TMZ mixed with POH (TMZ + POH, each at either 50 or 60 μM), and colony-forming ability was determined. Shown are photographic images of colonies formed in each well, which represent highly representative results from several repeats of this experiment. Note that equimolar mixes of TMZ + POH are unable to achieve the superior cytotoxicity of the conjugated compounds in NEO212Back to article page