Fig. 4
From: TGF-β induces HLA-G expression through inhibiting miR-152 in gastric cancer cells
TGF-beta induced HLA-G expression by inhibiting miR-152. BGC823 and SGC7901 cells were transfected with miR-152 mimics for 12 h, then incubated for 12 h (for qPCR analysis) or 24 h (for ELISA analysis) and finally treated with TGF-β (5 ng/ml). TGF-β induced increase of mRNA level (a) or concentration (b) of HLA-G was attenuated by miR-152 overexpression. *P < 0.05; **P < 0.01. c. The expression of miR-152 in GC tissues was inversely proportional to the HLA-G levels of GC patients. R2 = 0.5267; p < 0.001. D. MiR-152 expression levels also showed inversely proportional to the concentration of TGF-β. R2 = 0.5944; p < 0.001