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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells

Fig. 6

The effect of FA upstream gene knockdowns on proliferation and FANCD2 monoubiquitination in A549/DDP cells. a Knockdown of FANCF, FANCL, or both them markedly inhibited the proliferation rates, and (b, c) reduced FANCD2 monoubiquitination levels after treatment with cisplatin. (d) Knockdown of FANCD2, or double knockdown of FANCD2 and FANCF, or and FANCL significantly suppressed the proliferation rates, and (e, f) reduced FANCD2 monoubiquitination levels after treatment with cisplatin

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Journal of Biomedical Science

ISSN: 1423-0127