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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: An approach to the immunophenotypic features of circulating CD4+NKG2D+ T cells in invasive cervical carcinoma

Fig. 5

Plasma levels of pro-inflammatory cytokines are significantly diminished in cervical cancer patients. Using a commercial magnetic bead-based immunoassay, multiple cytokines were quantified in plasmas from cervical cancer patients or control women. Here again, control and cervical cancer groups were divided into the three different ranges of CD4+NKG2D+ T cells (0–2, 2–4, and >4 %). Systemic levels of IL-1β (a), TNF-α (b), and IL-2 (c) negatively correlated with the number of CD4+NKG2D+ T cells in cervical cancer patients (IL-1β: Spearman ρ = -0.408; p = 0.023; TNF-α: Spearman ρ = -0.394; p = 0.028; IL-2: Spearman ρ = -0.522; p = 0.003). The cytokine IL-10 was also negatively correlated in patient samples, accordingly with the increase of CD4+NKG2D+ T cells (Spearman ρ = -0.414; p = 0.021), as shown in (d)

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