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Table 3 Effect of miR-130b-MV injection for 10 days on the apparent and blood biochemical parameters in mice

From: Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ

Parameters

HF-SC-MV

HF-130b-MV

P Value

Sampling parameters

   

Body weight (g)

29.75 ± 0.53

26.30 ± 0.90

0.000

Epididymal fat weight (mg)

1.02 ± 0.09

0.72 ± 0.09

0.034

Liver weight (mg)

1.18 ± 0.05

1.17 ± 0.06

0.822

Muscle weight (mg)

0.34 ± 0.02

0.29 ± 0.01

0.025

Epididymal fat weight/Body weight

0.034 ± 0.003

0.027 ± 0.003

0.063

Liver weight/Body weight

0.039 ± 0.002

0.045 ± 0.002

0.004

Muscle weight/Body weight

0.011 ± 0.005

0.011 ± 0.005

0.825

Biochemical parameters

   

ALT (U/L)

10.83 ± 1.72

10.45 ± 1.84

0.882

AST (U/L)

53.64 ± 5.68

52.50 ± 2.00

0.858

GLU (mmol/L)

11.92 ± 0.60

10.13 ± 0.74

0.074

TG (mmol/L)

0.55 ± 0.04

0.44 ± 0.04

0.109

Tch (mmol/L)

2.59 ± 0.13

2.41 ± 0.14

0.334

HDLc (mmol/L)

1.46 ± 0.08

1.33 ± 0.05

0.167

LDLc (mmol/L)

0.15 ± 0.02

0.20 ± 0.03

0.066

NEFA (μmol /L)

857.67 ± 41.17

879.82 ± 56.14

0.751

Hormones and cytokines

   

IL-6 (pg/mL)

69.94 ± 14.17

216.98 ± 96.37

0.163

Insulin (pg/mL)

1668.54 ± 243.60

1618.35 ± 223.44

0.881

Leptin (pg/mL)

2566.43 ± 421.64

2289.77 ± 550.37

0.698

TNF-α (pg/mL)

6.66 ± 0.48

7.81 ± 0.69

0.194

  1. Notes: HF, high fat; HF-SC-MV, high fat diet induced obese mice injected with miR-SC-MV; HF-130b-MV, high fat diet induced obese mice injected with miR-130b-MV; The values shown represent the means ± SEM; P < 0.05 means significant difference compared with the HF-SC-MV group; n = 12