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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Involvement of gelsolin in TGF-beta 1 induced epithelial to mesenchymal transition in breast cancer cells

Fig. 2

Effects of GSN op on cell proliferation, cell cycle progression, and the expression of GSK-3β, β-catenine, and cyclin D1 in MDA-MB231 and MCF-7 breast cancer cells. GSN overexpression increased the doubling time for cell proliferation in stable GSN-overexpressing (GSN op) clones of (a) MDA-MB231, and (c) MCF-7 breast cancer cells as compared to their controls (Ctr), respectively. Flow cytometry determined the cell population at different cell cycle phases: G0/G1, S, and G2 in control and GSN op cells of (b) MDA-MB231, and (d) MCF-7 cells, respectively. e GSN overexpression altered the protein levels and mRNA expression of GSK-3β, β-catenin, cyclin D1 in MDA-MB231 or MCF-7 cells. β-actin used as an internal control. In a, b, c, d and e, the values are the mean ± SEM (n = 6), with * indicating a significant difference compared to the cells in control and GSN op, respectively

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