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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction

Fig. 4

GK-6, similarly to NGF, induces the differentiation of PC12 cells, whereas GK-2 does not. PC12 cells were treated with GK-6 (10-6M), GK-2 (10-5 and 10-8M) or NGF (10-9M) 3 times in 48 h. Cell differentiation was studied morphometrically. Magnification: 20×. a – untreated control cells, b – treatment with NGF, c – treatment with GK-6, d – treatment with GK-2 (10-5 M), e-treatment with GK-2 (10-8M). The bar in the photomicrographs corresponds to 25 μm

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