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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction

Fig. 5

Effects of the AKT kinase inhibitor LY294002 on the neuroprotection provided by GK-2 or NGF against H2O2-induced oxidative stress in HT-22 cells. Hippocampal cells, HT-22, were pre-incubated with LY294002 (100 μM) for 30 min before treatment with GK-2 (10-5M and 10-8M) or NGF (10-9M). Cell survival after a 30-min exposure to H2O2 was measured by assessment of MTT metabolism. Data are presented as means±SD. * p < 0.05 compared with control, ^ p < 0.05 compared with H2O2 group, # p < 0.05 compared with corresponding H2O2 + GK-2 or NGF + GK-2 (Kruskal–Wallis ANOVA test with Dunn’s post hoc)

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