Fig. 5From: FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPKFcγRIIB crosslinking reduces the number PCs resulting from the BCR-independent differentiation of CD27+ memory and CD27− naïve B cells. CD27+ and CD27− B cells from eight donors were treated with CpG as in Fig. 4 at various concentrations of isotype matched control or AT10 mAbs (0, 2, 5, or 10 μg/ml) for five days. The number of IgM- and IgG-antibody-secreting PCs was determined by ELISPOT assay. The asterisks indicate that the differences between the groups compared are statistically significant (P < 0.05)Back to article page