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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK

Fig. 5

FcγRIIB crosslinking reduces the number PCs resulting from the BCR-independent differentiation of CD27+ memory and CD27 naïve B cells. CD27+ and CD27 B cells from eight donors were treated with CpG as in Fig. 4 at various concentrations of isotype matched control or AT10 mAbs (0, 2, 5, or 10 μg/ml) for five days. The number of IgM- and IgG-antibody-secreting PCs was determined by ELISPOT assay. The asterisks indicate that the differences between the groups compared are statistically significant (P < 0.05)

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