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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice

Fig. 6

Scheme showing multiple age-related factors regulating hematopoietic stem cell function. Alterations in HSC function observed in aging: generation and main types of damage induced by ROS, different mechanisms of oxidative cellular/molecular damage and the potential role of antioxidants on HSC fate during the aging process. Lines with arrowhead indicate stimulation and lines with crosshead indicate inhibition. A line with a double arrowhead indicates a normal condition. Abbreviations: hematopoietic stem cells (HSC), reactive oxygen species (ROS), NADPH oxidase (NADPHox), cytochrome P450 (CYP450), xanthine oxidase (XO), lymphoid cells (L), myeloid cells (M), tumoral necrosis factor (TNF), interleukin-12p70 (IL-12), interleukin-6 (IL-6)

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