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Table 1 Effects of aging on body weight, hematopoietic stem cell number, cell cycle profile and cytokines levels in C57BL/6 J mice

From: Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice

Parameters Groups
Young Middle Aged
Body weight (g) 28 ± 1 29 ± 1 34 ± 1*
Hematopoietic stem cells (x106) 1.7 ± 0.2 4.3 ± 1 5.6 ± 1#
Cell cycle (%)    
 Sub G0 1 ± 0.2 4 ± 0.2 5 ± 0.5*
 G0/G1 81 ± 2.6 75 ± 2.3 66 ± 2.9*
 S/G2/M 18 ± 2.5 21 ± 2.6 29 ± 2.8*
Myeloid Cytokines (pg/mL)    
 IL-6 23 ± 2 28 ± 2 63 ± 8*
 TNF 111 ± 7 122 ± 7 227 ± 27*
 IL-12p70 141 ± 11 142 ± 10 203 ± 14*
Lymphoid Cytokines (pg/mL)    
 IFN-γ 3.2 ± 0.5 3.3 ± 0.6 4.1 ± 0.3
 IL-10 181 ± 17 164 ± 16 149 ± 8
  1. Values are means ± SEM for six to 11 animals per group. *p < 0.05 vs young and middle age; # p < 0.05 vs young (one-way ANOVA)