TY - JOUR AU - Cheng, Chih-Lun AU - Huang, Shin-Jie AU - Wu, Chih-Lu AU - Gong, Hong-Yi AU - Ken, Chuian-Fu AU - Hu, Shao-Yang AU - Wu, Jen-Leih PY - 2015 DA - 2015/11/17 TI - Transgenic expression of omega-3 PUFA synthesis genes improves zebrafish survival during Vibrio vulnificus infection JO - Journal of Biomedical Science SP - 103 VL - 22 IS - 1 AB - Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects to prevent alcoholic fatty liver syndrome or cholestatic liver injury. However, it is unclear how n-3 PUFAs improve immune function in liver. Vibrio vulnificus, a gram-negative bacterial pathogen, causes high mortality of aquaculture fishes upon infection. Humans can become infected with V. vulnificus through open wounds or by eating raw seafood, and such infections may result in systemic septicemia. Moreover, patients with liver diseases are vulnerable to infection, and are more likely than healthy persons to present with liver inflammation following infection. This study quantified n-3 PUFAs and their anti-bacterial effects in Fadsd6 and Elvol5a transgenic zebrafish. SN - 1423-0127 UR - https://doi.org/10.1186/s12929-015-0208-1 DO - 10.1186/s12929-015-0208-1 ID - Cheng2015 ER -