Fig. 1

Sequence alignment of human HRASLS enzymes. Sequence alignment was performed using ClustalW2 [51]. The C-terminal transmembrane-spanning hydrophobic region is underlined. The NCEHFV motif is highlighted in red with the active site cysteine bolded and italicized. The remaining two active sites in the catalytic triad are also bolded, and are highlighted in purple. Conserved residues are highlighted in yellow, and homologous residues are highlighted in grey