Table 1 Genotype distribution of REN gene tag-SNPs between control and ADPKD patients
From: Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD
Gene | Genotype | Control n (%) | ADPKD n (%) | OR (95 % CI) | p-Value (df-2) |
|---|---|---|---|---|---|
rs2887284 | CC | 70 (66) | 58 (56.8) | Reference | |
CA | 33 (31.1) | 38 (37.2) | 1.39 (0.78–2.49) | ||
AA | 3 (2.83) | 6 (5.8) | 2.41 (0.58–10.08) | 0.301 | |
MAF | 18.4 | 24.5 | |||
HWE-p | 0.703 | 0.945 | |||
rs2368564 | CC | 65 (61.3) | 54 (52.9) | Reference | |
TC | 38 (35.8) | 42 (41.1) | 1.33 (0.75–2.35) | ||
TT | 3 (2.83) | 6 (5.8) | 2.41 (0.58–10.08) | 0.343 | |
MAF | 20.75 | 26.47 | |||
HWE-p | 0.355 | 0.559 | |||
rs1464816 | GG | 58 (54.7) | 56 (54.9) | Reference | |
TG | 40 (37.7) | 41 (40.2) | 1.06 (0.60–1.88) | ||
TT | 8 (7.5) | 5 (4.9) | 0.65 (0.20–2.10) | 0.718 | |
MAF | 26.4 | 25 | |||
HWE-p | 0.762 | 0.467 | |||
rs7521667 | GG | 85 (80.2) | 76 (74.5) | Reference | |
TG | 20 (18.8) | 26 (25.5) | 1.45 (0.75–2.81) | ||
TT | 1 (0.94) | 0 | - | 0.430 | |
MAF | 10.38 | 12.75 | |||
HWE-p | 0.882 | 0.14 | |||
rs10900555 | TT | 52 (49.0) | 43 (42.1) | Reference | |
TC | 35 (33.0) | 46 (45.1) | 1.59 (0.88–2.89) | ||
CC | 19 (17.9) | 13 (12.7) | 0.83 (0.37–1.87) | 0.836 | |
MAF | 34.4 | 35.3 | |||
HWE-p | 0.005 | 0.898 | |||
rs6693954 | TT | 56 (52.8) | 48 (47.0) | Reference | |
TA | 46 (43.4) | 46 (45.1) | 1.17 (0.67–2.05) | ||
AA | 4 (3.7) | 8 (7.8) | 2.33 (0.66–8.23) | 0.283 | |
MAF | 25.47 | 30.3 | |||
HWE-p | 0.14 | 0.505 | |||
rs6676670 | GG | 73 (68.8) | 77 (75.5) | Reference | |
TG | 28 (26.4) | 22 (21.6) | 0.75 (0.39–1.42) | ||
TT | 5 (4.7) | 3 (2.94) | 0.57 (0.13–2.47) | 0.171 | |
MAF | 17.9 | 13.7 | |||
HWE-p | 0.292 | 0.367 | |||
rs11571078 | CC | 76 (71.7) | 71 (69.6) | Reference | |
TC | 28 (26.4) | 28 (27.4) | 1.07 (0.58–1.98) | ||
TT | 2 (1.89) | 3 (2.94) | 1.61 (0.26–9.89) | 0.659 | |
MAF | 15.09 | 16.67 | |||
HWE-p | 0.753 | 0.905 |