Table 3 Association between CKD stages and hypertension stratified by REN genotypes
From: Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD
Gene | Genotype | OR (95 % CI for HT) | p-Value* |
|---|---|---|---|
rs2887284 | CC | 3.0 (0.29–30.69) | |
CA | 5.73 (1.00–32.67) | ||
AA | 0.75 (0.43–1.32) | 0.36 | |
M-H Combined | 3.42 (0.97–12.07) | ||
rs2368564 | CC | 1.92 (0.16–22.56) | |
TC | 6.67 (1.21–36.74) | ||
TT | 0.75 (0.43–1.32) | 0.286 | |
M-H Combined | 3.42 (0.97–12.07) | ||
rs1464816 | GG | 3.94 (0.76–20.30) | |
TG | 3.0 (0.48–18.65) | ||
TT | 0.828 | ||
M-H Combined | 3.52 (1.04–11.90) | ||
rs7521667 | GG | 2.83 (0.53–15.02) | |
TG | 8.4 (1.27–55.39) | ||
TT | 3.66 (1.10–12.13) | 0.394 | |
M-H Combined | 4.47 (1.28–15.58) | ||
rs10900555 | TT | 1.09 (0.16–7.31) | |
TC | 11.73 (1.33–103.79) | ||
CC | 4.67 (0.30–73.38) | 0.227 | |
M-H Combined | 3.80 (1.16–12.48) | ||
rs6693954 | TT | 1.91 (0.16–22.63) | |
TA | 4.60 (0.82–22.88) | ||
AA | 0.83 (0.58–1.19) | 0.502 | |
M-H Combined | 2.84 (0.77–10.51) | ||
rs6676670 | GG | 3.55 (0.90–13.96) | |
TG | 2.75 (0.21–35.84) | ||
TT | 0.863 | ||
M-H Combined | 3.37 (1.01–11.26) | ||
rs11571078 | CC | 3.75 (0.70–20.03) | |
TC | 2.27 (0.36–14.45) | ||
TT | 0.594 | ||
M-H Combined | 3.01 (0.88–10.37) | ||