Fig. 5
TJY-16 inhibits the growth of glioma cells in vivo by inducing apoptosis. a 1 × 106 U87 glioma cells inoculated subcutaneously into the right flank of nude mice (n = 6 for each group). When the tumors reached 40 to 80 mm3 in volume, TJY-16 (24 mg/kg) were administered intraperitoneally every 24 h for 10 days and tumor volume was measured for another 20 days after the cessation of treatment. Temozolomide (TMZ, positive control) was given orally once per day for 5 days. *P < 0.05 vs. control. b Mice with xenograft U87 tumors were photographed after treatment with TJY-16 or control. c Western blots showed induction of caspase-3 activation at day 22 and day 42