Fig. 1

CTEPH plasma shows increased levels of endothelium-derived microparticles compared with pulmonary embolic and healthy controls. a Scanning electron microscope images of MP fractions.from a healthy volunteer, CTEPH and PE patients. Bar = 2 μm. b Number of membrane (PKH26⁺) MPs and c number of VE-cadherin⁺ (CD144⁺) MPs in plasma of healthy voulnteers, CTEPH and PE patients, as indicated; d Endoglin levels in MP fractions; ELISA assay; e endothelial angiogenesis (Matrigel tube formation) in HPAECs cultured with MPs isolated from CTEPH, PE or healthy plasma, as indicated. **P < 0.01; *P < 0.05, comparisons with healthy controls, ^## P < 0.01; ^# P < 0.05, comparisons with CTEPH; N = 4-6. Representative images of tube formation are shown beside the graph. Bar = 50 μm