The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation

Table 3 Relationship between PTEN expression and clinicopathological data in CRC patients

Clinicopathological features	N.	PTEN protein expression					P-value
Clinicopathological features	N.	0	1+	2+	3+	PR (%)	P-value
Total cases (cancerous)	125	41	34	37	13	67.2
Age							0.943
< 50	18	6	4	6	2	66.7
≥ 50	107	35	30	31	11	67.2
Sex							0.251
Female	55	15	16	18	6	72.7
Male	70	26	18	19	7	62.8
Tumor size (cm)							0.007
≤ 5	79	19	23	27	10	76
> 5	46	22	11	10	3	52.2
TNM Stage							0.011
I & II	25	3	6	12	4	88
III & IV	100	38	28	25	9	62
Tumor Differentiation							0.534
High	65	19	17	18	11	70.8
Moderate	49	17	14	16	2	65.3
Low	11	5	3	3	0	54.5
PTEN Promoter methylation							0.013
Methylated	39	18	15	4	2	53.8
Unmethylated	86	23	19	33	11	73.2

ISSN: 1423-0127