Fig. 5

Extensive collagen deposition in wild type and Sdc1 ^-/- mice with subacute peritoneal dialysis. At the study endpoint, samples of the abdominal wall were taken from (a) baseline control mice, (b) undialyzed animals that were injected with S. aureus and (c) mice that were treated with peritoneal dialysis for 4 weeks and infected with S. aureus 4 h before the endpoint. The sections were stained with picro-sirius red to visualize collagen fibers. The thickened peritoneal layer of dialyzed mice was rich in collagen fibers that were disorganized in both, the wild type and Sdc1 ^-/- mice. Representative images, n = 14 mice in the wild type infected non-PD group and wild type PD group, n = 8 mice in all other groups, (a & b) scale bar = 50 μm and (c) scale bar = 100 μm