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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine

Fig. 5

Legend. Anti-IL-18 blockade of TC-1-transplanted C57BL/6 mice during E7 DNA vaccination in combination with α-GalCer and MPL reduced the IFN- γ secretion. One week following the final blockade and vaccine administration, splenocytes were isolated and restimulated with E749–57 epitopes as described in Materials and Methods. The production of IFN- γ was measured from the supernatants of these restimulations by ELISA. Data are representative of three separate experiments. Data presented as means ± S.D. for three mice per group. Treatment groups were compared to the control group using one-way ANOVA. *** Indicates statistically significant difference (P < 0.001) between E7 DNA vaccine plus α-GalCer and MPL combination mice in the presence of anti-IL-18 mAbs over E7 DNA vaccine plus α-GalCer and MPL combination in the presence of isotype control

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Journal of Biomedical Science

ISSN: 1423-0127