Fig. 3

Amphetamine-induced hyperlocomotor activity in the control group [pretreatment with 5ECdsRan (panels a & b) or saline (panels c & d) before amphetamine] is reversed to near normal levels when mice were pretreated with 5ECdsAP1 (panels a – d) or 5ECdsNF-kB (panels c & d). Other control group not shown in this graph is pretreatment with ssAP-1 (fully phosphorothioate-modified). Fine motor movement (front paw movement without changing body position) is shows as frequency per minute (panel b). Distance traveled is given at speed (m per hr (panel a) or in centimeters at each interval of 5 min (panels c & d, which was calculated by the frequency of ambulation (locomotion between adjacent beams of light of 5 cm in one minute) x 5 cm per minute x 5 min per recoding interval. Typically, normal mice without treatment exhibited no more than 30 ambulation frequency per min within 15 min after handling (baseline). No significance was found between the control (saline) and dsAP-1 of Full EC (panel c)