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Table 1 Summary of the surface targeting and oAβ internalization of mutants in N-glycosylation sites of human SR-AI

From: Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO

Mutants Complex glycan structure Surface targeting oAβ internalization
N82Q
N102Q
N143Q
N184Q
N221Q
N249Q
N267Q
N102Q- N143Q
N102Q- N184Q
N143Q- N184Q
  1. Complex glycan structure is able to be cleavage by PNGase F but not by Endo H; Hybrid and high mannose type glycans is able to be cleavage by both PNGase F and Endo H
  2. ✚, mutants are glycosylated in complex structure, surface-targeted or internalize normal amount of oAβ
  3. ━, mutants are not glycosylated in complex structure
  4. , mutants are less glycosylated in complex structure or internalize less amount oAβ