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Table 3 Summary of the surface targeting of mutants in SRCR domain of human MARCO

From: Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO

Mutants

Mutation position

Surface targeting

R425A

β1

R432A

Loop-β2

G433A

β2

R434A

β2

R436A

β2

W443A

β3

I457A

α1

V458A

α1

F459A

α1

C460A

disulfide bond

L463A

loop

L471A

β4-loop

V486A

loop

H510A

η2

D513A

loop

  1. Mutation position represents the location of mutated residues in the simulated-structure of SRCR domain
  2. ✚, mutants are surface-targeted
  3. ━, mutants are not surface-targeted