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Table 3 Summary of the surface targeting of mutants in SRCR domain of human MARCO

From: Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO

Mutants Mutation position Surface targeting
R425A β1
R432A Loop-β2
G433A β2
R434A β2
R436A β2
W443A β3
I457A α1
V458A α1
F459A α1
C460A disulfide bond
L463A loop
L471A β4-loop
V486A loop
H510A η2
D513A loop
  1. Mutation position represents the location of mutated residues in the simulated-structure of SRCR domain
  2. ✚, mutants are surface-targeted
  3. ━, mutants are not surface-targeted