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Table 2 Pharmacokinetic parameters calculated following oral administration (PO: single dose of 50 mg/kg body weight) and intravenous administration (IV: single dose of 5 mg/kg body weight) of andrographolide in female BALB/c mice

From: Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line

PK parameters

PO at 50 mg/kg

IV at 5 mg/kg

AUC(0-8) (μmol.h/L)

1.92 ± 0.36

1.96 ± 0.38

AUC(0-∞) (μmol.h/L)

2.33 ± 0.42

2.52 ± 0.56

Cmax (μmol/L)

0.73 ± 0.17

ND

Tmax (h)

0.42 ± 0.14

ND

C0 (μmol/L)

ND

14.57 ± 4.04

CL (L/h/kg)

62.68 ± 12.10

5.52 ± 1.09

Terminal T½ (h)

3.30 ± 0.35

1.87 ± 0.21

Bioavailability (%)

9.27 ± 1.69

ND

  1. ND = Not determined; AUC(0-8) is the total area under the curve from time 0 to 8 h; AUC(0-∞) is the total area under the curve from time 0 extrapolated to infinite time combined with an extrapolated value; C0 is the drug concentration at time 0; CL is the drug clearance; Terminal T1/2 is the time for concentration to decrease by one-half in the elimination phase; Cmax is the maximum concentration observed; Tmax is the time at maximum concentration observed; Bioavailability is the fraction of administered drug that reached the systemic circulation
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Journal of Biomedical Science

ISSN: 1423-0127