Fig. 2
Resveratrol evoked the BKCa channel responses in human cortical (HCN-1A) neurons. In these experiments, cells were bathed in high-K+ solution and cell-attached current recordings were made. The holding potential was constantly set at +60 mV. a Original current trace obtained in the absence (left) and presence (right) of 10 μM resveratrol. Resveratrol was applied to the bath solution. The upward deflection indicates the opening events of the channels. b Bar graph showing the effect of resveratrol and resveratrol plus paxilline on the open probability of BKCa channels. Each bar indicates the mean ± SEM (n = 7-9). Res: 10 μM resveratrol; Pax: 1 μM paxilline. *Significantly different from control (P < 0.05). #Significantly different from resveratrol alone group (P < 0.01)