Fig. 3

Concentration-dependent effect of resveratrol on voltage-gated sodium currents. The cells were bathed in Ca²⁺-free, Tyrode's solution. a Functional expression of the voltage-gated sodium current in embryonic rat cortical neurons. Superimposed current traces in control (top panel) and during exposure to 2 μM TTX (lower panel). Under the experimental condition, depolarizing voltage command from a holding potential of −80 mV elicited an inward current sensitive to TTX. This inward Na⁺ current was maximally activated by a test pulse at −20 mV (n = 8). b Concentration dependent effects of resveratrol on inward Na⁺ currents. The currents were evoked depolarizing the cells from a holding potential of −80 mV to −20 mV. Representative traces showing the depression of inward Na⁺ currents by resveratrol at different concentrations in these cells. c The graph shows the concentration dependent effect of resveratrol on the amplitudes of the inward currents measured at the peaks (n = 3-5). ^*Significantly different from control group (P < 0.05)