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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels

Fig. 4

Resveratrol reduced action potential firing in embryonic rat cortical neuron. Current-clamp configuration was made in these experiments. All cells were bathed in Tyrode’s solution containing 1.8 mM CaCl2. Trains of action potentials were evoked by a depolarizing current step. a Original potential traces obtained in control (upper) and in the presence (lower) of resveratrol (20 μM) by injecting a threshold current. b The potential traces obtained in the absence and presence of TTX (2 μM). c The potential traces obtained in the absence and presence of NS1619 (5 μM). In the presence of resveratrol, TTX, and NS1619, the action potential firing frequency was significantly decreased

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