Fig. 5From: Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channelsResveratrol reduced TEA- or paxilline-evoked increases in action potential firing in embryonic rat cortical neuron. a Action potential firing was measured in control, in the presence of TEA (1 mM), and TEA combined with resveratrol (20 μM). b Action potential firing was measured in control, in the presence of paxilline (20 μM), and paxilline combined with resveratrol (20 μM). TEA and paxilline significantly increased the action potential firing frequency. Upon application of 20 μM resveratrol in the presence of TEA and paxilline, the excitability was suppressed significantlyBack to article page