Fig. 5

NAD + −induced transient AP prolongation in the presence of selective P2X antagonists in LA preparations. a relative APD90 measured at the moment of maximal AP prolongation in the absence of blockers and in the presence of P2X blockers iso-PPADS (1 μM) or Evans Blue (0.1 μM). APD90 is expressed in % of APD90 measured right before NAD+ application. * - significant difference from the effect of NAD+ alone, Mann–Whitney test, p < 0.05. b time course of APD90 changes induced by NAD+ in the presence of 0.1 μM Evans Blue and traces of APs recorded in the moments marked with numbers of respective color at the time course curve