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Table 1 Case–control studies reporting plasma or serum peroxidation biomarkers and Total Antioxidant Capacity in psoriasis: association with inflammation and lipid profile

From: Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis

Ref. Case/control Peroxidation TAC Inflammation Lipid profile
[18] 100/100 ↑ MDA    ↑ CHOL, LDL
↔ HDL, TG
[19] 100/100 ↑ MDA   ↑VAP-1 ↑ CHOL, LDL
↔ HDL, TG
[20] 25/20: 10/10 smokers ↑ MDA    
15/10 non-smokers ↑ MDA
[21] 29/18 ↑MDA/TBARS ↑ROS  
[22] 30/10: 10 mild    
10 moderate    
10 severe    
[23] 35/25 ↑ MDA   
[24] 32/32 ↑ MDA    
[25] 8/8 ↑ peroxides   
[26] 34/37 ↑ TBARS, oxLDL ↑ CRP ↑ CHOL, LDL, TG
↓ HDL
[27] 73/38 ↑ TBARS ↑CRP  
[28] 67/35 ↑ TBARS    
[29] 58/45 ↑ MDA   
[30] 54/62: 28/16 smokers ↑ TOS   ↔ CHOL, LDL, HDL, TG
26/46 non-smokers ↑ TOS   ↔ CHOL, LDL, HDL, TG
[31] 23/25: 12 mild (1) ↑ peroxides and dienes   ↔ CRP ↔ CHOL, LDL, HDL, TG
11 severe (2) ↑ peroxides and dienes   ↔ CRP ↔ CHOL, LDL, HDL, TG
[32] 55/20: 11 mild, ↑ MDA   
20 moderate ↑ MDA   
24 severe ↑ MDA   
[33] 7/6    
[34] 16/16 ↑ TBARS   
[35] 59/40 ↑ MDA   ↑ IL-6  
[36] 90/30: 30 mild ↑ MDA   
30 moderate ↑ MDA   
30 severe ↑ MDA   
[37] 39/25 ↑ TOC   
[38] 60/47 ↑ peroxides   
[39] 32/20 ↔ TBARS    
[40] 40/20 ↑ peroxides    
[41] 127/389 ↑ peroxides    
[42] 100/100: 29 Mild ↑ MDA    ↑ CHOL, LDL
     ↔ HDL, TG
60 Moderate ↑ MDA    ↑ CHOL, LDL
     ↔ HDL, TG
11 Severe ↑ MDA    ↑ CHOL, LDL
     ↔ HDL, TG
[43]      ↑ CHOL, TG
30/33 ↑ oxLDL   ↑ ESR ↔ LDL
     ↓ HDL
[44] 24/26 ↑ MDA   ↑ IL-8  
[45] 90/90: 30 mild ↑ MDA    
30 moderate ↑ MDA    
30 severe ↑ MDA    
[46] 40/40: 34 remission ↔ MDA    
6 acute ↑ MDA    
[47] 60/30: 30 inactive psoriasis ↑ TBARS   ↔CHOL, LDL, TG
     ↓ HDL
30 active psoriasis ↑ TBARS   ↑ CHOL, LDL, TG ↓ HDL
[48] 60/40: 30 inactive psoriasis ↑ TBARS ↑ CRP  
30 active psoriasis ↑ TBARS ↑ CRP  
[49] 48/40: 24 inactive psoriasis ↑ TBARS   ↔CHOL, LDL, TG
     ↓ HDL
24 active psoriasis ↑ TBARS   ↑ CHOL, LDL, TG ↓ HDL
[50] 33/36    
[51] 23/23 ↑ MDA    
[52] 45/45 ↑ MDA    ↑ CHOL, LDL, ↔ HDL, TG
[53] 40/47 ↑ TOS   
[54] 30/23 ↔ MDA   ↔ CHOL, LDL, HDL, TG
[55] 52/25: 25 with MS ↔ TOS   ↑ CHOL, LDL, TG
     ↓ HDL
27 without MS ↔ TOS   ↔ CHOL, LDL, HDL, TG
[56] 35/35 ↑ MDA, oxLDL CRP, ESR↑ ↑ CHOL, LDL, TG ↓ HDL
[57] 67/35 ↑ TBARS    
[58] 22/22 ↔ MDA    
  1. CHOL: cholesterol; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; HDL: high-density lipoprotein; IL: interleukin; LDL: low-density lipoprotein; MDA: malondialdehyde; MS: metabolic syndrome; oxLDL: oxidized low-density lipoprotein; ROS: reactive oxygen species; TAC: total antioxidant capacity; TBARS: thiobarbituric acid reactive substance; TG: triglycerides; TOC: total oxidant capacity, also named total oxidant status (TOS); VAP-1: vascular adhesion protein-1; ↑: increased; ↓: decreased; ↔: unchanged