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Table 2 Intervention studies reporting plasma or serum peroxidation biomarkers and Total Antioxidant Capacity in psoriasis: association with inflammation and lipid profile

From: Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis

Ref. N° subjects: Treatment Peroxidation TAC Inflammation Lipid profile
Duration (study design)
[33] 7: topical treatmenta    
Single application
[28] 67: topical treatmentb ↓ TBARS    
20 days
[57] 67: topical treatmentb ↓ TBARS    
20 days
[26] 10: topical treatmentc ↓ TBARS ↔ CRP ↔ CHOL, LDL, HDL, TG
↔ oxLDL
11: NB UVB ↔ TBARS, oxLDL ↓ CRP ↔ CHOL, LDL, HDL, TG
13: PUVA ↔ TBARS, oxLDL ↓ CRP ↔ CHOL, LDL, HDL, TG
3, 6, and 12 weeks (3 treatments in parallel)
[27] 10: topical treatmentc ↓ TBARS ↔ CRP  
17: NB UVB ↓ TBARS ↓ CRP  
20: PUVA ↓ TBARS ↓ CRP  
3, 6, and 12 weeks (2 treatments in parallel)
[39] 32: BB UVB ↑ TBARS    
21 weeks (longitudinal)
[59] 24: NB UVB ↑ TOS ↔ CRP  
30 sessions (longitudinal)
[60] 3: MMF ↔ MDA   ↔ CRP  
1 months (longitudinal)
[29] 58: MTX ↑ MDA   
6 and 12 weeks (longitudinal)
[61] 26: MTX ↔ TOS   ↓ CHOL, LDL, HDL
8 weeks (longitudinal)
[21] 13: Infliximab ↓ MDA ↓ ROS  
6 months (parallel: treated versus 16 untreated patients)
[62] 23: Etanercept ↓ peroxides ↓ CRP ↔ CHOL, LDL, HDL, TG
24 weeks (longitudinal)
[44] 24: Efalizumab ↓ MDA   ↔ IL-8  
12-week (longitudinal) ↓ Ex-vivo TNF-α and IFN-γ
  1. BB UVB: broad-band UVB; CHOL: cholesterol; CRP: C-reactive protein; HDL: high-density lipoprotein; IFN: interferon; IL: interleukin; LDL: low-density lipoprotein; MDA: malondialdehyde; MMF: mycophenolate mofetil; MTX: Methotrexate; NB UVB: narrow-band UVB; oxLDL: oxidized low-density lipoprotein; PUVA: photochemotherapy; ROS: reactive oxygen species; TAC: total antioxidant capacity; TBARS: thiobarbituric acid reactive substance; TG: triglycerides; TNF: tumor necrosis factor; TOS: total oxidant status; Topical treatment: afluocinolone acetonide, bsalicyl ointment, cignoline, tar, followed by bethametasone dipropionide with salicyl acid, ccalcipotriene (calcipotriol) or betamethasone dipropionate, or a combination of the two; ↑: increased; ↓: decreased; ↔: unchanged