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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: A new age for biomedical applications of Ribosome Inactivating Proteins (RIPs): from bioconjugate to nanoconstructs

Fig. 1

Enzymatic and structural properties of RIPs. a RIPs recognize α-sarcin/ricin loop (SRL), highlighted in grey, of rRNA 28S on ribosomes. Depurination of A4234 (see text) by N-glycosilase activity inhibits role of eukaryotic elongation factor 2 (eEF2) in the promotion of the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome, with consequent arrest of protein synthesis. b Structural representation of type 1 RIPs (single enzymatic chain) and type 2 RIPs (dimeric protein consisting of an enzymatic chain and a lectin domain)

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Journal of Biomedical Science

ISSN: 1423-0127