Fig. 4

The recombinant virus rNDV-P53 suppresses the growth of H22 xenografts in mice. A xenograft H22 animal model was established in mice. When the tumor size reached to about 50 mm³ (about 7 days post-inoculation), the tumors were injected with 1 × 10⁷ pfu of rNDV or rNDV-P53 virus (day 0). The PBS was used as control. The injections were repeated every 2 days during experimental period. Mice were killed when the tumors reached 18 mm in length. On day 18, all mice from the control group and 6 mice from each treatment group were sacrificed and their tumors were excised. The remaining 8 mice in each treatment group were observed for 120 days with measurement of tumor volume. a The tumor growth was observed by measuring the tumor size every 2 days for 18 days. b The weight of the excised tumors of different groups. c The excised tumors of different groups. d Before necropsy, the tumor in the right groin of different groups mice. e The percent survival of tumor-bearing mice treated with PBS, rNDV, and rNDV-P53 in the 120 days (**p < 0.01; *p < 0.05)