Fig. 6

Effect of the combinational treatment with tamoxifen and CSC-3436 on tumor growth in MDA-MB-231 xenograft model. Each 5 week-old nude mouse was performed by s. c. injection of MDA-MB-231 cells. Mice were randomly assigned to seven groups (n = 9), and oral administrations treated with tamoxifen (2 mg/kg), CSC-3436 (10, 20 and 40 mg/kg, respectively) and the tamoxifen (2 mg/kg) plus CSC-3436 (5, 10, and 20 mg/kg, respectively). a Mean body weights, b mean tumor volumes, c tumor weights for each treatment group. *p < 0.05 compared with vehicle-treated group