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Table 3 Univariate and multivariate Cox regression analyses of risk factors for cancer-related death in early-stage LUAD patients

From: A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations

  TVGH (N = 69)a TCGA (N = 299)a
Characteristics Univariate analysis Multivariate analysisc Univariate analysis   Multivariate analysisc
HR (95 % CI)b p-valueb HR (95 % CI)b p-valueb HR (95 % CI)b p-valueb HR (95 % CI)b p-valueb
Eight-probe panel
 Risk < Median 1.00   1.00   1.00   1.00  
 Risk > Median 2.37 (1.24–4.53) 0.009 2.03 (1.04–3.98) 0.039 1.66 (1.03–2.66) 0.038 1.57 (0.96–2.57) 0.073
Gender
 Male 1.00   -   1.00   -  
 Female 1.43 (0.71–2.88) 0.321 - - 0.78 (0.49–1.26) 0.315 - -
Stage
 Stage IA 1.00   1.00   1.00   1.00  
 Stage IB 2.13 (0.73–6.16) 0.164 2.01 (0.69–5.86) 0.199 1.15 (0.63–2.11) 0.642 1.17 (0.63–2.16) 0.616
 Stage IIA 8.76 (2.10–36.53) 0.003 5.79 (0.72–46.58) 0.099 2.17 (0.98–4.81) 0.057 0.85 (0.21–3.38) 0.817
 Stage IIB 6.11 (1.81–20.64) 0.003 3.65 (0.70–18.92) 0.124 2.04 (1.07–3.91) 0.031 0.91 (0.26–3.15) 0.885
T stage
 Stage 1–2 1.00   -   1.00   -  
 Stage 3–4 2.22 (0.53–9.28) 0.277 - - 0.62 (0.15–2.53) 0.502 - -
T stage
 Stage 1 1.00   -   1.00   -  
 Stage 2 1.23 (0.56–2.68) 0.613 -   1.28 (0.77–2.12) 0.338 -  
 Stage 3 2.59 (0.54–12.32) 0.232 - - 0.72 (0.17–3.07) 0.657 - -
N stage
 N0 1.00   1.00   1.00   1.00  
  ≥ N1 3.95 (1.88–8.30) 0.001 1.54 (0.35–6.91) 0.571 2.27 (1.38–3.73) 0.001 2.51 (0.74–8.43) 0.138
Chemotherapy
 No 1.00   -      
 Yes 1.84 (0.92–3.69) 0.084 - -     
TKI treatment
 No 1.00   -      
 Yes 2.03 (0.79–5.26) 0.144 - -     
Surgery
 Lobectomy 1.00   -      
 Wedge resection 1.35 (0.53–3.45) 0.536 -      
 Segmentectomy 2.98 (0.40–22.31) 0.288 - -     
  1. aTVGH: Taipei Veterans General Hospital; TCGA: The Cancer Genome Atlas
  2. bCI, confidence interval; HR, hazard ratio. Bold values indicate statistical significance (p < 0.05)
  3. cThe variables without significant HR in the univariate analysis were not included in the multivariate analysis