Table 3 Univariate and multivariate Cox regression analyses of risk factors for cancer-related death in early-stage LUAD patients

 Risk < Median

1.00

1.00

1.00

1.00

 Risk > Median

2.37 (1.24–4.53)

0.009

2.03 (1.04–3.98)

0.039

1.66 (1.03–2.66)

0.038

1.57 (0.96–2.57)

0.073

 Male

1.00

-

1.00

-

 Female

1.43 (0.71–2.88)

0.321

-

-

0.78 (0.49–1.26)

0.315

-

-

 Stage IA

1.00

1.00

1.00

1.00

 Stage IB

2.13 (0.73–6.16)

0.164

2.01 (0.69–5.86)

0.199

1.15 (0.63–2.11)

0.642

1.17 (0.63–2.16)

0.616

 Stage IIA

8.76 (2.10–36.53)

0.003

5.79 (0.72–46.58)

0.099

2.17 (0.98–4.81)

0.057

0.85 (0.21–3.38)

0.817

 Stage IIB

6.11 (1.81–20.64)

0.003

3.65 (0.70–18.92)

0.124

2.04 (1.07–3.91)

0.031

0.91 (0.26–3.15)

0.885

 Stage 1–2

1.00

-

1.00

-

 Stage 3–4

2.22 (0.53–9.28)

0.277

-

-

0.62 (0.15–2.53)

0.502

-

-

 Stage 1

1.00

-

1.00

-

 Stage 2

1.23 (0.56–2.68)

0.613

-

1.28 (0.77–2.12)

0.338

-

 Stage 3

2.59 (0.54–12.32)

0.232

-

-

0.72 (0.17–3.07)

0.657

-

-

 N0

1.00

1.00

1.00

1.00

  ≥ N1

3.95 (1.88–8.30)

0.001

1.54 (0.35–6.91)

0.571

2.27 (1.38–3.73)

0.001

2.51 (0.74–8.43)

0.138

 No

1.00

-

 Yes

1.84 (0.92–3.69)

0.084

-

-

 No

1.00

-

 Yes

2.03 (0.79–5.26)

0.144

-

-

 Lobectomy

1.00

-

 Wedge resection

1.35 (0.53–3.45)

0.536

-

 Segmentectomy

2.98 (0.40–22.31)

0.288

-

-