Fig. 4

Gnmt−/− mice developed hepatic steatosis and increased de novo lipogenesis in the liver. a Hepatic and b serum levels of triglycerides and VLDL in 11-week-old WT and Gnmt−/− mice (n = 6 per group). c. Expression of genes that encode lipogenetic transcription factors (PPARγ and Srebp1c) and enzymes (Fasn, Mttp, Acsl4, Scd1 and Acc) in the liver of Gnmt−/− mice (n = 4 per group). * p < 0.05 (between WT and Gnmt−/− mice); ** p < 0.01 (between WT and Gnmt−/− mice); ^# p < 0.05 (between male and female Gnmt−/− mice); ^## p < 0.01 (between male and female Gnmt−/− mice)