Fig. 7From: Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liverIllustration of proposed mechanism underlying GNMT deficiency induced triglycerides accumulation and insulin resistance in the liver. GNMT deficiency may enhance lipogenesis to cause hepatic triglycerides accumulation, thus impairing insulin signaling and gluconeogenesis, especially in female Gnmt−/− miceBack to article page