Fig. 2

Phasic fold-changes relative to sham-controls of sumo1 or ubc9 mRNA in the RVLM determined by real-time PCR after intravenous administration of saline or LPS (10 mg kg⁻¹). Tissue samples were collected during the peak of Phases I, II or III in the LPS group; or 20 (I), 150 (II) or 300 (III) min in the saline group. Values are mean ± SEM of triplicate analyses on individual samples obtained from 4–5 animals per experimental group. *P < 0.05 versus sham-control group or corresponding saline group in the post hoc Scheffé multiple-range test