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Table 1 Oncogenic and tumor suppressor Rab proteins in cancers

From: Rab-mediated vesicle trafficking in cancer

Rab protein Cancer types Expression Clinical implications References
Rab1 Colon Increased Elevated cell invasion,
poor prognosis
[50]
Liver Increased Elevated cell invasion,
poor prognosis
[51]
Brain Increased Poor survival [52]
Rab2 Breast Increased Expansion of stem-like cells,
poor prognosis
[44]
Rab3 Breast Increased Elevated cell motility [45]
Brain Increased Tumor progression [81]
Rab4 Breast Increased Elevated cell motility [82]
Rab5 Lung Increased activity Elevated cell motility [83]
Rab11 Breast Increased activity Elevated cell invasion [39]
Rab17 Liver Decreased Elevated clinical tumor
characteristics
[84]
Rab21 Cervical cancer Increased Elevated cell motility [46]
Rab23 Stomach Increased Poor prognosis [47]
Rab25 Ovarian, Breast Increased Poor prognosis [48]
Esophagus Decreased Poor survival [55]
Colon Decreased Poor survival [56]
Rab27 Breast Increased Poor prognosis [42]
Rab31 Breast Increased Poor survival [85]
Rab35 Not applicable Gain of function mutations Anti-apoptosis [49]
Rab37 Lung Decreased Poor prognosis [58, 59]
Rab38 Brain Increased Poor prognosis [86]