Rab-mediated vesicle trafficking in cancer

Table 1 Oncogenic and tumor suppressor Rab proteins in cancers

Rab protein	Cancer types	Expression	Clinical implications	References
Rab1	Colon	Increased	Elevated cell invasion, poor prognosis	[50]
	Liver	Increased	Elevated cell invasion, poor prognosis	[51]
	Brain	Increased	Poor survival	[52]
Rab2	Breast	Increased	Expansion of stem-like cells, poor prognosis	[44]
Rab3	Breast	Increased	Elevated cell motility	[45]
Rab3	Brain	Increased	Tumor progression	[81]
Rab4	Breast	Increased	Elevated cell motility	[82]
Rab5	Lung	Increased activity	Elevated cell motility	[83]
Rab11	Breast	Increased activity	Elevated cell invasion	[39]
Rab17	Liver	Decreased	Elevated clinical tumor characteristics	[84]
Rab21	Cervical cancer	Increased	Elevated cell motility	[46]
Rab23	Stomach	Increased	Poor prognosis	[47]
Rab25	Ovarian, Breast	Increased	Poor prognosis	[48]
	Esophagus	Decreased	Poor survival	[55]
	Colon	Decreased	Poor survival	[56]
Rab27	Breast	Increased	Poor prognosis	[42]
Rab31	Breast	Increased	Poor survival	[85]
Rab35	Not applicable	Gain of function mutations	Anti-apoptosis	[49]
Rab37	Lung	Decreased	Poor prognosis	[58, 59]
Rab38	Brain	Increased	Poor prognosis	[86]

ISSN: 1423-0127