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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

Fig. 2

The effect of berberine on TDP-43 aggregates formation. a GFP-tagged aggregation-prone TDP-43 fragments (GFP-TDP-25) were transfected in N2a cells. After 6 h or 24 h transfection, N2a cells were treated with different dose of berberine for another 24 h. GFP-TDP-25-transfected N2a cells were then stained with anti-GFP antibody (green) in immunofluorescence assay. The nuclei were stained with DAPI (blue). b The histogram showing the percentage of cells with GFP-TDP-43 aggregates. Data are presented as mean ± s.e.m. of three independent experiments *p < 0.05; **p < 0.01 (Student’s t-test compared with the control)

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