Fig. 5
From: A disease spectrum for ITPA variation: advances in biochemical and clinical research
Pathways for drug bioactivation and drug degradation by ITPase. a Thiopurine metabolism. Based on [7, 36]. b Ribavirin metabolism. AZA: azathioprine; 6-TG, 6-thioguanine; 6-MP: 6-mercaptopurine; 6-TIMP, 6-TIDP, 6-TITP: 6-thio-inosine 5′-mono-, di- and tri-phosphate; 6-TGMP, 6-TGTP: 6-thio-guanosine 5′-mono- and tri-phosphate; 6-Me-TIMP, 6-Me-TITP: 6-methylthio-inosine 5′-mono- and tri-phosphate. RBV: ribavirin; RBVMP, RBVDP, RBVTP: ribavirin 5′-mono-, di- and tri-phosphate; HGPRT: hypoxanthine-guanine phosphoribosyltransferase; TPMT: thiopurine S-methyltransferase; NMPK, NDPK: nucleoside mono- and di-phosphate kinase; ADK: adenosine kinase