Fig. 1

Drosophila porin has a conserved Porin3_VDAC domain. The Drosophila melanogaster porin gene encodes a 282 amino acids protein and the Porin domain is highly conserved when compared to the human homologue. It shows presence of a nuclear export signal (NES), a transmembrane domain, and a PDZ domain. Domains were identified using the NCBI Conserved Domain Database Search (CDD) [29] and the Eukaryotic Linear Motif resource search [30]. A Clustal Omega multiple sequence alignment [31, 32] show conservation of the porin3_VDAC domain (Hsap is Homo sapiens NP_003366.2, Dmel is Drosophila melanogaster NP_001033899.1 and Agam is Anopheles gambiae XP_318947.2). “*” indicate the residues that are identical, “:” indicate the conserved substitutions, “.” indicate the semi-conserved substitutions. Colours show the chemical nature of amino acids. Red is small hydrophobic (including aromatic), Blue is acidic, Magenta is basic, and Green is basic with hydroxyl or amine groups