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Table 2 Dictyostelium proteins homologous to human NCL proteins

From: Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Human protein

Size (aa)

Dictyostelium homolog (dictyBase ID)

Size (aa)

Region of similarity (aa)

Identities (%)

Positives (%)

E-value

PPT1/CLN1

Accession: NP_000301

306

Ppt1 (DDB0233890)

303

273

46

69

8.00E-80

TPP1/CLN2

Accession: NP_000382

563

Tpp1 (DDB0234303)

600

552

36

52

4.00E-91

CLN3

Accession: NP_000077

438

Cln3 (DDB0233983)

421

429

27

45

3.00E-31

DNAJC5/CLN4

Accession: NP_079495

198

Ddj1 (DDB0215016)

411

69

57

76

2.00E-18

CLN5

Accession: NP_006484

407

Cln5 (DDB0234077)

322

301

30

47

2.00E-27

CLN6

Accession: NP_060352

311

No homolog

MFSD8/CLN7

Accession: NP_689991

518

Mfsd8 (DDB0307149)

498

530

29

47

1.00E-41

CLN8

Accession: NP_061764

286

No homolog

CTSD/CLN10

Accession: NP_001900

412

CtsD (DDB0215012)

383

359

47

66

9.00E-91

PGRN/CLN11

Accession: NP_002078

593

Grn (DDB0238428)

130

47

55

68

2.00E-08

ATP13A2/CLN12

Accession: NP_071372

1180

Kil2 (DDB0237611)

1158

1089

35

53

1.00E-175

CTSF/CLN13

Accession: NP_003784

484

CprA (DDB0201647)

343

340

37

55

6.00E-64

KCTD7/CLN14

Accession: NP_694578

289

Kctd9 (DDB0231824)

488

96

38

58

2.00E-11

  1. The amino acid sequences of human NCL proteins were inputted into the BLASTp server of dictyBase (http://www.dictybase.org). The following parameters were set: E-value, 1000; Matrix, BLOSUM62; Filter, no