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Table 2 Dictyostelium proteins homologous to human NCL proteins

From: Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Human protein Size (aa) Dictyostelium homolog (dictyBase ID) Size (aa) Region of similarity (aa) Identities (%) Positives (%) E-value
PPT1/CLN1
Accession: NP_000301
306 Ppt1 (DDB0233890) 303 273 46 69 8.00E-80
TPP1/CLN2
Accession: NP_000382
563 Tpp1 (DDB0234303) 600 552 36 52 4.00E-91
CLN3
Accession: NP_000077
438 Cln3 (DDB0233983) 421 429 27 45 3.00E-31
DNAJC5/CLN4
Accession: NP_079495
198 Ddj1 (DDB0215016) 411 69 57 76 2.00E-18
CLN5
Accession: NP_006484
407 Cln5 (DDB0234077) 322 301 30 47 2.00E-27
CLN6
Accession: NP_060352
311 No homolog
MFSD8/CLN7
Accession: NP_689991
518 Mfsd8 (DDB0307149) 498 530 29 47 1.00E-41
CLN8
Accession: NP_061764
286 No homolog
CTSD/CLN10
Accession: NP_001900
412 CtsD (DDB0215012) 383 359 47 66 9.00E-91
PGRN/CLN11
Accession: NP_002078
593 Grn (DDB0238428) 130 47 55 68 2.00E-08
ATP13A2/CLN12
Accession: NP_071372
1180 Kil2 (DDB0237611) 1158 1089 35 53 1.00E-175
CTSF/CLN13
Accession: NP_003784
484 CprA (DDB0201647) 343 340 37 55 6.00E-64
KCTD7/CLN14
Accession: NP_694578
289 Kctd9 (DDB0231824) 488 96 38 58 2.00E-11
  1. The amino acid sequences of human NCL proteins were inputted into the BLASTp server of dictyBase (http://www.dictybase.org). The following parameters were set: E-value, 1000; Matrix, BLOSUM62; Filter, no