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Table 4 Localization of NCL homologs in Dictyostelium and other systems

From: Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Dictyostelium homolog

dictyBase ID

Localization in Dictyostelium

Localization of human protein (or homologs in other systems)

Ppt1

DDB0233890

Extracellular space [40]

Macropinocytic pathway [32]

Cytoplasmic vesicles [21]

Endoplasmic reticulum [21]

Lipid rafts [21]

Lysosomal matrix [21]

Presynaptic areas in neurons [21]

Tpp1

DDB0234303

Lysosome [14]

Endoplasmic reticulum [21]

Lysosomal matrix [21]

Cln3

DDB0233983

CV system [13, 15]

Endocytic pathway [13, 15]

Macropinocytic pathway [32]

Late endosomal membrane [21]

Lysosomal membrane [21]

Ddj1

DDB0215016

Centrosome [69]

Macropinocytic pathway [32]

Phagosome [70]

Cell membrane [68]

Cytoplasm [21]

Melanosomes [67]

Synaptic vesicles in neurons [21] Secretory granules in endocrine, neurocrine and exocrine cells [21]

Vesicular membranes [21]

Cln5

DDB0234077

Macropinocytic pathway [32]

Extracellular space [76]

Lysosomal matrix [21, 75]

Mfsd8

DDB0307149

Macropinocytic pathway [32]

Lysosomal membrane [21]

CtsD

DDB0215012

Endocytic pathway (e.g., phagosome, lysosome) [81–83]

Macropinocytic pathway [32]

Extracellular space [21, 79, 80]

Lysosomal matrix [21]

Grn

DDB0238428

Not known

Extracellular space [21, 97]

Kil2

DDB0237611

Macropinocytic pathway [32]

Phagosomal membrane [102]

Lysosomal membrane [21, 99, 100]

Multi-vesicular bodies [21, 99, 100]

CprA

DDB0201647

Not known

Lysosomal matrix [21]

Kctd9

DDB0231824

Not known

Cell membrane [21, 114] Punctate cytoplasmic distributions [21, 114]