Skip to main content

Advertisement

Table 4 Localization of NCL homologs in Dictyostelium and other systems

From: Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Dictyostelium homolog dictyBase ID Localization in Dictyostelium Localization of human protein (or homologs in other systems)
Ppt1 DDB0233890 Extracellular space [40]
Macropinocytic pathway [32]
Cytoplasmic vesicles [21]
Endoplasmic reticulum [21]
Lipid rafts [21]
Lysosomal matrix [21]
Presynaptic areas in neurons [21]
Tpp1 DDB0234303 Lysosome [14] Endoplasmic reticulum [21]
Lysosomal matrix [21]
Cln3 DDB0233983 CV system [13, 15]
Endocytic pathway [13, 15]
Macropinocytic pathway [32]
Late endosomal membrane [21]
Lysosomal membrane [21]
Ddj1 DDB0215016 Centrosome [69]
Macropinocytic pathway [32]
Phagosome [70]
Cell membrane [68]
Cytoplasm [21]
Melanosomes [67]
Synaptic vesicles in neurons [21] Secretory granules in endocrine, neurocrine and exocrine cells [21]
Vesicular membranes [21]
Cln5 DDB0234077 Macropinocytic pathway [32] Extracellular space [76]
Lysosomal matrix [21, 75]
Mfsd8 DDB0307149 Macropinocytic pathway [32] Lysosomal membrane [21]
CtsD DDB0215012 Endocytic pathway (e.g., phagosome, lysosome) [8183]
Macropinocytic pathway [32]
Extracellular space [21, 79, 80]
Lysosomal matrix [21]
Grn DDB0238428 Not known Extracellular space [21, 97]
Kil2 DDB0237611 Macropinocytic pathway [32]
Phagosomal membrane [102]
Lysosomal membrane [21, 99, 100]
Multi-vesicular bodies [21, 99, 100]
CprA DDB0201647 Not known Lysosomal matrix [21]
Kctd9 DDB0231824 Not known Cell membrane [21, 114] Punctate cytoplasmic distributions [21, 114]