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Table 5 Cellular processes modulated by NCL homologs in Dictyostelium and other systems

From: Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Dictyostelium homolog dictyBase ID Processes modulated in Dictyostelium Knockout mutant generated Processes modulated by human protein (or homologs in other systems)
Ppt1 DDB0233890 Phagocytosis [41] No Apoptosis [21]
Cholesterol metabolism [21]
Phagocytosis [42]
Recycling of synaptic vesicles [21]
Tpp1 DDB0234303 Autophagy [14]
Pre-spore cell differentiation [14]
Timing of mid-stage development [14]
Yes [14] Endocytosis [21] Macroautophagy [21]
TNF-α-induced apoptosis [21]
Cln3 DDB0233983 Cell proliferation [13]
Pinocytosis [13]
Protein secretion and cleavage [13]
Cell adhesion [15]
Timing of mid-stage development [15]
Timing of late-stage development [15]
Response to bacterial pathogens [66]
Yes [13] Apoptosis [21]
Autophagy [21]
Calcium homeostasis [21]
Cell cycle control [21]
Endocytosis [21]
Intracellular trafficking [21] Lysosomal pH homeostasis [21]
Osmoregulation [21]
Ddj1 DDB0215016 Phagocytosis [70] No Presynaptic endocytosis and exocytosis [21]
Cln5 DDB0234077 Not known No Apoptosis [21]
Cell growth [21]
Myelination [21]
Sorting and recycling of lysosomal receptors [21]
Sphingolipid transport and synthesis [21]
Mfsd8 DDB0307149 Not known No Predicted to have a role in:
Transport of small substrates across the lysosomal membrane [21]
CtsD DDB0215012 Bacterial killing [86]
Cell death [88, 89]
Timing of early-stage development [81]
Yes [79] Apoptosis [21, 90]
Autophagy [21, 91]
Cell migration [85]
Innate immune response [87]
Grn DDB0238428 Not known No Autophagy [21, 97]
Cell migration [21, 97]
Embryogenesis [21, 97]
Inflammation [21, 97]
Tumorigenesis [21, 97]
Kil2 DDB0237611 Bacterial killing [102, 105]
Predation on yeast [104]
Yes [100] Predicted to have a role in:
Lysosomal degradation [21]
pH and biometal homeostasis within lysosomes [21]
Transport across cellular membranes [21]
CprA DDB0201647 Early-stage development [108]
Osmoregulation [110]
No Autophagy [21]
Cell immunity [21, 113]
Lipoprotein degradation [21]
Proteasome degradation [21]
Kctd9 DDB0231824 Not known Yes [118] Predicted to have a role in:
Hyperpolarization of the neuronal cell membrane [21]
Proteasome degradation [21]