Table 5 Cellular processes modulated by NCL homologs in Dictyostelium and other systems
Dictyostelium homolog | dictyBase ID | Processes modulated in Dictyostelium | Knockout mutant generated | Processes modulated by human protein (or homologs in other systems) |
|---|---|---|---|---|
Ppt1 | DDB0233890 | Phagocytosis [41] | No | Apoptosis [21] Cholesterol metabolism [21] Phagocytosis [42] Recycling of synaptic vesicles [21] |
Tpp1 | DDB0234303 | Autophagy [14] Pre-spore cell differentiation [14] Timing of mid-stage development [14] | Yes [14] | Endocytosis [21] Macroautophagy [21] TNF-α-induced apoptosis [21] |
Cln3 | DDB0233983 | Cell proliferation [13] Pinocytosis [13] Protein secretion and cleavage [13] Cell adhesion [15] Timing of mid-stage development [15] Timing of late-stage development [15] Response to bacterial pathogens [66] | Yes [13] | Apoptosis [21] Autophagy [21] Calcium homeostasis [21] Cell cycle control [21] Endocytosis [21] Intracellular trafficking [21] Lysosomal pH homeostasis [21] Osmoregulation [21] |
Ddj1 | DDB0215016 | Phagocytosis [70] | No | Presynaptic endocytosis and exocytosis [21] |
Cln5 | DDB0234077 | Not known | No | Apoptosis [21] Cell growth [21] Myelination [21] Sorting and recycling of lysosomal receptors [21] Sphingolipid transport and synthesis [21] |
Mfsd8 | DDB0307149 | Not known | No | Predicted to have a role in: Transport of small substrates across the lysosomal membrane [21] |
CtsD | DDB0215012 | Bacterial killing [86] Timing of early-stage development [81] | Yes [79] | Cell migration [85] Innate immune response [87] |
Grn | DDB0238428 | Not known | No | |
Kil2 | DDB0237611 | Predation on yeast [104] | Yes [100] | Predicted to have a role in: Lysosomal degradation [21] pH and biometal homeostasis within lysosomes [21] Transport across cellular membranes [21] |
CprA | DDB0201647 | Early-stage development [108] Osmoregulation [110] | No | Autophagy [21] Lipoprotein degradation [21] Proteasome degradation [21] |
Kctd9 | DDB0231824 | Not known | Yes [118] | Predicted to have a role in: Hyperpolarization of the neuronal cell membrane [21] Proteasome degradation [21] |